Volume 4, Issue 3 (Aug 2016)                   Res Mol Med (RMM) 2016, 4(3): 29-34 | Back to browse issues page

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Tahmaseni Fard Z, Hasanzad M, Nowroozi M R, zham H. Association between the Asp327Asn Polymorphism of Sex Hormone-Binding Globulin Gene and Prostate Cancer. Res Mol Med (RMM). 2016; 4 (3) :29-34
1- Assistant Professor of cellular and Molecular Biology, Roudehen Branch, Islamic Azad University, Roudehen, IRAN. ,
2- Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3- Uro Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
4- Department of pathology , Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IRAN & Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IRAN
Abstract:   (8692 Views)

Background: By binding SHBG hormone to sex hormones, in addition to carrying them in the blood, they regulate the amount of tissue availability. Since the genetic changes in the structure of globulin affect it’s binding to hormones, so in this study the effects of single nucleotide change in exon 8 or rs 6259 in the incidence of prostate cancer is evaluated.

Methods: The study population included 120 patients with prostate cancer and 120 control subjects. After collecting blood samples, DNA was extracted by salting out the method in order to determine the genotype of individuals by RFLP-PCR method. According to Hardy-Weinberg equilibrium genotypes and allele frequencies were calculated and a relationship between this variation and prostate cancer were evaluated and by using SPSS 23 software and the relationship between variations. The significance level was considered ≤0.05.

Results: Results indicated that homozygous mutant genotype AA 2.58 (p value= 0.007, OR: 2.58, CI95%: 1.52-4.38) and heterozygous AG 1.18 times (p-value =0.5, OR: 1.18, CI95%: 0.38-3.61) increase chance of getting prostate cancer in carriers. But homozygous of wild genotype GG have the protective role against prostate cancer (p-value =0.005, OR: 0.385, CI95%: 0.23-0.65).

Conclusion: Therefore, Asn allele is one of the main factors in prostate cancer so it can be used as the non-invasive and suitable marker for early detection in susceptible individuals.

Full-Text [PDF 577 kb]   (1241 Downloads)    
Type of Study: Research | Subject: Medical Education
Received: 2016/09/2 | Accepted: 2016/09/24 | Published: 2016/09/24

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