دوره 4، شماره 2 - ( بهار 1395 )                   جلد 4 شماره 2 صفحات 35-30 | برگشت به فهرست نسخه ها


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Banitalebi E, Gharakhanlou R. Correlations Between Plasma Sphingosine-1-phosphate (S1P) and Gene Expression of S1P Receptors with Mogenic Regulatory Factors Following Resistance Training. Res Mol Med (RMM) 2016; 4 (2) :30-35
URL: http://rmm.mazums.ac.ir/article-1-182-fa.html
Correlations Between Plasma Sphingosine-1-phosphate (S1P) and Gene Expression of S1P Receptors with Mogenic Regulatory Factors Following Resistance Training. Research in Molecular Medicine. 1395; 4 (2) :30-35

URL: http://rmm.mazums.ac.ir/article-1-182-fa.html


چکیده:   (4787 مشاهده)

Background: The purpose of present study was to investigate whether Sphingosine 1-phosphate (S1P) levels and its receptors gene expressions are correlated with MyoD and myogenin following resistance training.

Materials and Methods: 24 eight-week-old male Wistar rats (190-250 gr) were assigned randomly to a control (N = 12) or training (N = 12) group. Rats climbed a resistance training ladder with weights attached to their tails. The content of plasma S1P and relative mRNA expression were determined by high performance liquid chromatography (HPLC) and Real-time PCR, respectively.

Results: Resistance training increased the content of S1P in plasma (P = 0.001) and changed the gene expression of S1P1, S1P2 and S1P3 receptors. There were significant correlations between plasma S1P and gene expression of S1P2,3 receptors with gene expression of MyoD. There are correlations between satellite cells activation markers (MyoD and myogenin) and plasma S1P content and its receptors before and after resistance training.

Conclusion: It might be concluded that S1P as a growth mediator may play an important role in skeletal muscle adaptations.

متن کامل [PDF 612 kb]   (2159 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: بيولوژي
انتشار: 1395/3/22

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Research in Molecular Medicine می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Research in Molecular Medicine

Designed & Developed by : Yektaweb