Volume 4, Issue 1 (Feb 2016)                   Res Mol Med (RMM) 2016, 4(1): 1-4 | Back to browse issues page

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Infectious Diseases and Microbiology, The Children’s Hospital at Westmead and Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney NSW Australia , email: alison.kesson@health.nsw.gov.au
Abstract:   (3725 Views)

There are significant challenges associated with qualitative and quantitative nucleic acid tests performed in diagnostic laboratories. The development of internationally available certified reference materials which can be traced to reference measurements will contribute to a better understanding of the performance characteristics of nucleic acid tests and enhance reliability and comparability of clinical data.

Next generation sequencing may have a future role in the identification and resistance detection of clinical pathogens, however, the current complexity of bioinformatics to support this technology makes its routine use in a diagnostic laboratory problematic. However, next generation sequencing is starting to impact epidemiological studies used to investigate the pathways of disease transmission in outbreaks and to determine microbial populations in metagenomics studies.

Full-Text [PDF 359 kb]   (1677 Downloads)    
Type of Study: review | Subject: Microbiology
Received: 2015/12/19 | Accepted: 2016/02/9 | Published: 2016/02/9