Volume 4, Issue 3 (Aug 2016)                   Res Mol Med (RMM) 2016, 4(3): 17-21 | Back to browse issues page

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Nazari M, Nasiri M, Ghaderi A. Evaluation of Long Stress-Induced Non-coding Transcripts 5 Polymorphism in Iranian Patients with Bladder Cancer. Res Mol Med (RMM). 2016; 4 (3) :17-21
1- Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran
2- Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran ,
3- Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (4074 Views)

Background: Bladder cancer (BC) is the most commonly diagnosed genitourinary cancer in Iran, presented in both men and women. BC is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. Long stress-induced non-coding transcript 5 (LSINCT5), a member of the long non-coding RNAs, is abundantly expressed in high proliferative cells, as well as the cells vulnerable to cellular stress in response to chemical carcinogens.

This case-control study aimed to determine any association between LSINCT5 rs2962586 polymorphism and bladder cancer.

Materials and Methods: A group of 150 patients with BC were compared with 143 subjects as a control group. Genotyping of the rs2962586 polymorphism was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR) method.

Results: Genotype and allele distribution were not significantly different between the case and control groups. Smoking was found to be the confounding risk factor for bladder cancer.

Conclusion: Considering the result of our analyses, it seems that LSINCT5 could not affect individual susceptibility to BC among Iranian patients, however, it can be considered as a disease predictor among smokers.

Full-Text [PDF 505 kb]   (1382 Downloads)    
Type of Study: Research | Subject: Genetic
Received: 2016/06/10 | Accepted: 2016/08/13 | Published: 2016/08/13

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