en ايمونولوژي Immunology پژوهشي Research <p><strong>Background: </strong>Brucellosis is the major bacterial zoonoses of global importance caused by <i>Brucella spps.</i> FC&gamma;RIIA receptor plays a central role in phagocytosis of IgG2-opsonized bacteria. FC&gamma;RIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. Cells expressing Fc &gamma; RIIa-H131, bind more efficiently to complexes of IgG2 than those expressing the Fc &gamma; RII A -R131 variant. The purpose of this study was to evaluate the association of FC&gamma;RIIA polymorphisms with susceptibility to or severity of brucellosis.</p> <p><strong>Materials and Methods: </strong>In this study, we evaluated FC&gamma;RIIA polymorphisms (R/R131, R/H131, H/H131) in 67 patients with brucellosis and 67 age, sex and geographical matched healthy volunteers. FC&gamma;RIIA genotyping was performed by using a sequence-specific primer polymerase chain reaction (SSP-PCR).</p> <p><strong>Results: </strong>The comparison of the FC&gamma;RIIA genotypes distribution in patients with brucellosis and controls showed a higher frequency in FC&gamma;RIIA-R/R131 homozygosity in patients than controls (47.8% vs. 28.4%). Logistic regression analysis showed that there is a significant correlation between R/R131 genotype and brucellosis (OR=2.3, 95%CI=1.3-4.2, P=0.04). Although the frequency of the FC&gamma;RIIA-R/R131 was higher in patients with chronic brucellosis compared with acute brucellosis, we did not find any statistically significant differences (53.8% vs. 46.3%, P=0.65).</p> <p><strong>Conclusion: </strong>The result of this study showed that the homozygous genotype of FC&gamma;RIIA-R/R131 in patients with brucellosis may be associated with susceptibility to brucellosis as a genetic risk factor.</p> <p></p> Brucellosis, FCγRIIA, Polymorphism 17 22 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-25-3&slc_lang=en&sid=1 Zahra Hosseini khah 10031947532846006089 10031947532846006089 No 1Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Mazandaran, Iran Zohreh Bahadori 10031947532846006090 10031947532846006090 No 2Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Tehran, Iran Alireza Rafiei 10031947532846006091 10031947532846006091 Yes 1Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Mazandaran, Iran Mehrdad Hajilooi rafiei1710@gmail.com 10031947532846006092 10031947532846006092 No 3Department of Immunology, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran