Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1393
2
1
gregorian
2014
5
1
2
2
online
1
fulltext
en
Inflammation, a Key Factor in Cancer Ambush
ايمونولوژي
Immunology
review
review
<p class="MsoNormal" style="margin-bottom: 0.0001pt line-height: normal"><span style="font-size: 10pt font-family: 'Times New Roman', serif">Inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, UV radiation, stress and etc. Persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from T cells. These molecules (e.g. IL-6, TNF-&alpha, IL-1&beta and IL-17) are mostly <span style="background: white">pleiotropic</span> cytokines involved in multiple signaling cascades. NF-&kappaB, STAT3, and HIF-1&alpha are the major engaged pathways directing to several downstream targets associating with tumorigenesis and inflammation. Carcinogenesis processes such as DNA mutation/damage, proliferation, angiogenesis, apoptosis, and invasion are implicated to inflammation. Clearly there is a closely association between cancer and inflammation reported as “Seven Hallmark of Cancer”. The elucidation of relationship between inflammation and cancer and their interaction may result in effective therapy and prevention. Gastric cancer is one of the main cancer involved in complex correlation of inflammation and cancer. Inflammation in gastric epithelium could trigger cellular transformation and promote invasion by inducing immune responses and utilizing signaling cascades. Gastric tumor microenvironment has inverse association by providing cytokines and inflammatory mediators. This closely relationship facilitates gastric tumor development and the induction of chronic inflammation in tumor microenvironment. The current review will focus on describing the possible and critical ways in which inflammation and cancer are linked together with specific view to gastric cancer and inflammation. Finally, it introduces some putative treatment generally used in this way in order to direct more attention for further exploration. </span></p>
Inflammation, Cancer, Gastritis, Gastric cancer, Cytokines, Chemokines, Signaling pathway
1
15
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-615-2&slc_lang=en&sid=1
Omolbanin
Amjadi
prs.amjadi0o0@gmail.com
10031947532846006064
10031947532846006064
No
Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of MedicalSciences, Sari, Iran.
Alireza
Rafiei
rafiei1710@gmail.com
10031947532846006065
10031947532846006065
Yes
Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of MedicalSciences, Sari, Iran.
Abolghasem
Ajami
a.ajami@mazums.ac.ir
10031947532846006066
10031947532846006066
No
Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of MedicalSciences, Sari, Iran.
Vahid
Hosseini
10031947532846006067
10031947532846006067
No
Inflammatory Diseases of Upper GI Tract Research Center, Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Hossein
Asgarian-Omran
10031947532846006068
10031947532846006068
No
Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of MedicalSciences, Sari, Iran.