en زیست شناسی مولکولی Molecular biology review review <p style="text-align: justify;"><span style="line-height:2;"><span style="font-size:12px;"><span style="font-family:Tahoma;">Breast cancer is the most common cancer in females. The treatment of this cancer is one of the challenges facing the world&rsquo;s health system. Metastasis and cancer cell invasion are the reasons for the difficulty in treating this cancer. Also, the formation of new blood vessels, or angiogenesis, facilitates metastasis in cancer patients. Therefore, researchers are seeking new therapeutic drugs. One of the important factors in the processes of angiogenesis and metastasis is vascular endothelial growth factor and its receptor. Agents that can inhibit this molecule and its receptor will have helpful therapeutic potential for treating breast cancer. Apatinib is a drug that has drawn the attention of cancer researchers in the last decade, and many studies have been conducted on its effectiveness in cancer treatment, especially breast cancer. In this review article, we aimed to summarize the therapeutic potential of apatinib in vivo and animal models, with a focus on clinical trials.</span></span></span></p> Apatinib, Breast cancer, Clinical trials, Metastasis 131 142 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1357-2&slc_lang=en&sid=1 Mohammad Naderi Alizadeh m.biochem76@gmil.com 100319475328460013436 100319475328460013436 No Functional Neurosurgey Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Ehsan Rahimlou erahimlou@yahoo.com 100319475328460013437 100319475328460013437 No Department of Medical Laboratory Sciences, MAR.C., Islamic Azad University, Marand, Iran. Elham Rahimlou e.rahimloo@yahoo.com 100319475328460013438 100319475328460013438 No Department of Medical Laboratory Sciences, MAR.C., Islamic Azad University, Marand, Iran. Vahid Vahedian vahid.vahedian@gmail.com 100319475328460013439 100319475328460013439 No Division of Hematology and Cellular Therapy/LIM-31, Department of Internal Medicine, Faculty of Medicine, Clinical Hospital, University of São Paulo, São Paulo, Brazil. Mahdi Gharibi mahdi.gharibi@yahoo.com 100319475328460013440 100319475328460013440 No Department of Pharmacy, Faculty of Pharmacy, University of Ankara, Ankara, Turkey. Nahal Soltani nahalsoltani1399@gmail.com 100319475328460013441 0009-0005-2164-8580 No Department of Medical Laboratory Sciences, MAR.C., Islamic Azad University, Marand, Iran. Nazila Fathi Maroufi n.fathi6788@gmail.com 100319475328460013442 100319475328460013442 Yes Department of Pharmacy, Faculty of Pharmacy, University of Ankara, Ankara, Turkey.