en ايمونولوژي Immunology review review <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;">Inflammation, whether aseptic or induced by pathogenic microorganisms, serves as a protective mechanism of the immune system. While the current pharmacological agents used to mitigate inflammation are effective, they are associated with numerous adverse effects. Thus, it is imperative to explore alternative therapies that offer greater efficacy and fewer side effects. Certain phytochemicals, such as eugenol, are effective in alleviating inflammation. This study aims to thoroughly review and synthesize existing literature on the effects of eugenol administration in managing various inflammatory disorders in laboratory and animal experimental models. Eugenol and its derivatives have been successful in reducing inflammation in laboratory studies but have been ineffective in reaching clinical trials. Issues include differences between in vitro and in vivo responses, poor bioavailability, a short biological half-life, and eugenol&rsquo;s instability.&nbsp;</span></span></span></div> Inflammation, Phytochemicals, Eugenol, Non-steroidal anti-inflammatory drugs (NSAID), Inflammatory disorders 81 92 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1440-1&slc_lang=en&sid=1 Nazanin Joudaki n.joudaki74@gmail.com 100319475328460013397 100319475328460013397 No Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Alireza Rafiei rafiei1710@gmail.com 100319475328460013398 100319475328460013398 Yes Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Abolghasem Ajami ajami36@gmail.com 100319475328460013399 100319475328460013399 No Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Reza Jafari-Shakib jsh.reza@gmail.com 100319475328460013400 100319475328460013400 No Department of Microbiology and Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.