en پزشکي هسته اي Nuclear Medicine پژوهشي Research <strong>Background</strong>: Cisplatin is a potent chemotherapeutic agent whose clinical use is limited by acute nephrotoxicity. This study aimed to evaluate the impact of high-intensity interval training (HIIT) on renal function and histology in cisplatin-treated rats.&nbsp;<br> <strong>Materials and Methods:</strong> Thirty-two male Sprague-Dawley rats were assigned to four groups (n=8): Healthy control (HC): No intervention; cisplatin control (CC): Received cisplatin only (single intraperitoneal injection, 5 mg/kg); exercise control (Ex): Underwent 8-week HIIT protocol only (treadmill running), cisplatin+exercise (Cis+Ex): Received cisplatin + 8-week HIIT protocol. Nephrotoxicity was induced by a single intraperitoneal cisplatin injection (5 mg/kg). Serum creatinine and urea were measured, and kidney tissues were analyzed using stereological methods.&nbsp;<br> <strong>Results</strong>: Cisplatin administration significantly increased serum creatinine (CC: 1.28&plusmn;0.11 mg/dL vs HC: 0.45&plusmn;0.08 mg/dL, P=0.001) and urea (CC: 112.5&plusmn;8.4 mg/dL vs HC: 45.3&plusmn;5.1 mg/dL, P=0.001). HIIT in cisplatin-treated rats significantly reduced these levels (creatinine: C-HIIT: 0.68&plusmn;0.09 mg/dL vs CC, P=0.016; urea: C-HIIT: 58.7&plusmn;6.9 mg/dL vs CC, P=0.005). Stereological analysis revealed cisplatin-induced increases in kidney volume (P=0.003), glomerular volume (p=0.039), and cortical volume (P=0.02), which were significantly attenuated by HIIT (P<0.05 for all). &nbsp;<br> <strong>Conclusion</strong>: An 8-week HIIT protocol significantly ameliorated cisplatin-induced renal dysfunction and histological damage in rats. These findings highlight the potential of HIIT as a non-pharmacological strategy to mitigate chemotherapy-related nephrotoxicity. Cisplatin, High-intensity interval training (HIIT), Kidney histology, Creatinine, Urea, Nephrotoxicity 23 30 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1352-3&slc_lang=en&sid=1 Mohammad Parastesh M-parastesh@araku.ac.ir 100319475328460013352 100319475328460013352 Yes Department of Sport Physiology and Pathology, Faculty of Sports Sciences, Arak University, Arak, Iran. Abbas Parvaneh a-parvaneh@yahoo.com 100319475328460013353 0009-0007-8437-8340 No Department of Sport Physiology and Pathology, Faculty of Sports Sciences, Arak University, Arak, Iran. Abbas Saremi a-saremi@araku.ac.ir 100319475328460013354 100319475328460013354 No Department of Sport Physiology and Pathology, Faculty of Sports Sciences, Arak University, Arak, Iran. Behzad Aria b.aria@yazd.ac.ir 100319475328460013355 100319475328460013355 No Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran.