en زیست شناسی مولکولی Molecular biology پژوهشي Research <strong>Background</strong>: Menstrual blood has been identified as an important source for the isolation of mesenchymal stem cells (MSCs). These stem cells can easily and non-invasively be harvested from menstrual blood during menstrual shedding. There has been extensive research on the differentiation potential of menstrual blood-derived stem cells (MenSCs) and their application in regenerative medicine and the treatment of diseases.&nbsp;<br> <strong>Materials and Methods</strong>: The aim of this paper was to review the current and future application of MenSCs in the field of regenerative medicine and cell therapy based on an electronic search in various databases, like Scopus, PubMed, and Google Scholar for English-language studies. The application of MenSCs in regenerative medicine can be the window of hope for the treatment of various diseases and disabilities, such as female infertility, type 1 diabetes, myocardial infarction, wound healing, neurodegenerative diseases, and many other conditions that were thought to be incurable in the past.<br> <strong>Conclusion</strong>: Nowadays, the use of MenSC as a novel source of MSCs has garnered special interest among scientists due to two important factors: Non-invasive accessibility and the immunomodulatory potential of these cells, which have historically posed significant obstacles in the field of stem cell therapy. To date, there has been substantial research on these cells, and many studies are ongoing, as scientists seek to leverage their differentiation potential and optimize differentiation conditions and protocols for their application in regenerative medicine.&nbsp; Regenerative medicine, Menstrual blood-derived stem cells (MenSCs), Mesenchymal stem cell (MSC), Stem cell therapy 9 22 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-833-1&slc_lang=en&sid=1 Atefeh Hojat atefehhojjat@gmail.com 100319475328460013343 0009-0005-8043-7062 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Seyed Ehsan Enderami ehsan.enderami@gmail.com 100319475328460013344 100319475328460013344 Yes Department of Medical Biotechnology, Immunogenetics Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Reyhaneh Nassiri Mansour nassirireyhane@gmail.com 100319475328460013345 100319475328460013345 No Department of Medical Biotechnology, Immunogenetics Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Mohammad Kabi mohamad.kaabi@gmail.com 100319475328460013346 100319475328460013346 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Mohamadfoad Abazari Foadabazari@outlook.com 100319475328460013347 100319475328460013347 No Department of Neurosciences, University of British Columbia, Vancouver, Canada. Keyvan Mehdipour Chari keyvanmehdipour@gmail.com 100319475328460013348 100319475328460013348 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Amirali Khodashenas shabanalikhodashenas@gmail.com 100319475328460013349 100319475328460013349 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Vahid Kia vahidkiaa@gmail.com 100319475328460013350 100319475328460013350 No Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Amir Maleksabet amirmellati@gmail.com 100319475328460013351 100319475328460013351 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.