en پزشکي فيزيکي و توانبخشي Physical Medicine and Rehabilitation پژوهشي Research <div style="text-align: justify;"><span style="color:#000000;"><span style="font-size:14px;"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-family:" timesnewromanps-boldmt="">Background: </span></b><span style="font-family:" timesnewromanpsmt="">Platinum-based chemotherapy, a cornerstone in cancer treatment, can induce hepatotoxicity. Exercise can mitigate adverse effects of chemotherapy, including liver damage. This study aimed to investigate the protective effects of moderate-intensity continuous training (MICT) on liver function and lipid metabolism in rats induced with Platinol.</span></span></span><br> <span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-family:" timesnewromanps-boldmt=""><span style="color:#1d3b6a"></span>Materials and Methods: </span></b><span style="font-family:" timesnewromanpsmt="">Twenty-four male Sprague-Dawley rats were randomly divided into four groups: A healthy control group, a platinol-injected control group, a MICT group, and a platinolinjected group with MICT. Serum liver enzymes alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST) and lipid profiles were measured after 10 weeks of training or platinol injection.</span></span></span><br> <span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-family:" timesnewromanps-boldmt=""><span style="color:#1d3b6a"></span>Results: </span></b><span style="font-family:" timesnewromanpsmt="">MICT significantly reduced serum levels of AST, ALT and ALP in platinol-induced rats, comparable to healthy controls. Additionally, MICT improved lipid profiles by reducing cholesterol, triglycerides, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol (HDL).</span></span></span><br> <span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-family:" timesnewromanps-boldmt="">Conclusion: </span></b><span style="font-family:" timesnewromanpsmt="">MICT may be a promising intervention to mitigate platinum-induced liver toxicity and dyslipidemia. Further research is warranted to explore the potential clinical implications of these findings for cancer patients undergoing chemotherapy.</span></span></span></span></span></div> Platinol, moderate-intensity continuous training, liver, Lipid Profile 265 272 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1352-1&slc_lang=en&sid=1 Mohammad Parastesh M-parastesh@araku.ac.ir 100319475328460013128 100319475328460013128 No Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran. Behzad Aria b.aria@yazd.ac.ir 100319475328460013129 100319475328460013129 Yes Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran.