Research in Molecular Medicine

en The effect of the duration of orthognathic surgery on plasma concentration of Interleukin 6 جراحي دهان وفک وصورت Oral and Maxillofacial Surgery پژوهشي Research Background: The cytokines have a major role in the inflammatory response to surgery and trauma. They have local effects of mediating and maintaining the inflammatory response to tissue injury, and also initiate some of the systemic changes which occur. IL-6 is one of the above mentioned cytokines, but it is not clear whether the duration of trauma or surgery has some effect on IL-6 level, so the aim of this study was to investigate the relationship between plasma levels IL-6 and duration of orthognathic surgery. Materials and Methods: Twenty eight patients underwent orthognathic surgery were enrolled in this study. Blood samples were collected one day before and 4 hours after surgery for assessment the levels of plasma IL-6 which was measured by enzyme-linked immunosorbent essay. Results: We found a significant elevation of plasma IL-6 level at 4 hours after surgery (P<0.05). Moreover, the elevation of plasma IL-6 level was correlated with the duration of surgery. Conclusion: IL-6 is an important inflammatory mediator that its concentration is increased with the duration of surgery. Orthognathic surgery, Interleukin-6, Duration of surgery, Acute phase response 34 37 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-611-1&slc_lang=en&sid=1 Mandana Sattari mandana.sattari@gmail.com 0045160732 10031947532846005974 Yes Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran. Iran Ali Peymani Mojaver a_peymani@rums.ac.ir 10031947532846005975 10031947532846005975 No Department of Maxillo-facial Surgery, Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Hossein Behnia behnia_h@hotmail.com 10031947532846005976 10031947532846005976 No Department of Maxillo-facial Surgery, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran Golnaz Kavand golnaz-kavand@uiowa.edu 10031947532846005977 10031947532846005977 No Departments of Preventive and Community Dentistry, University of Iowa, College of Dentistry, Iowa, USA Hassan Darbandi-Tamijani 10031947532846005978 10031947532846005978 No Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran. Iran