fa آموزش پزشكی Medical Education پژوهشي Research <div style="text-align: justify;"><strong>Background:</strong> This research aims to investigate the performance of 8 weeks of aerobic exercise and vitamin D supplementation on nitric oxide (NO) and endothelin 1 (ET-1) indicators in patients with high blood pressure and vitamin D deficiency.</div> <div style="text-align: justify;"><strong>Materials and Methods:</strong> In this quasi-experimental research, 40 qualified men and women were randomly divided into four groups (supplement group, placebo + exercise group, supplement + exercise group, and control group). The training program of the experimental groups included 8 weeks of aerobic exercise running on a treadmill (3 sessions per week). Two groups (exercise + supplement and supplement group) received vitamin D supplement daily in the amount of 2000 international units in a double-blind manner, and the exercise + placebo group received a placebo capsule containing maltodextrin daily. Blood sampling was done to evaluate biochemical variables 48 hours before and after the intervention in a fasting state.</div> <div style="text-align: justify;"><strong>Results:</strong> The research results show that after 8 weeks of aerobic training with vitamin D supplementation, there was no significant effect on body mass index, NO, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), vitamin D, and weight (P<0.05), but the effects were significant on ET-1 level and systolic blood pressure which changed in the supplement, supplement+exercise, and exercise+placebo groups compared to the control group (P<0.05). Also, the vitamin D increase showed a significant change (P<0.05).</div> <div style="text-align: justify;"><strong>Conclusion: </strong>Based on the results of the present study, taking vitamin D supplements for 8 weeks along with aerobic activity reduces ET-1, increases NO, and improves blood pressure in hypertensive people with vitamin D deficiencies.</div> Vitamin D deficiency, Nitric oxide (NO), Endothelin 1 (ET-1), Aerobic exercise, High blood pressure, Vitamin D 187 194 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1301-2&slc_lang=fa&sid=1 Mozaffar Janfaza aram.janfaza71@gmail.com 100319475328460012081 100319475328460012081 Yes Department of Exercise Physiology and Corrective Exercises, Faculty of Sports Sciences, Urmia University, Urmia, Iran. Mahsa Bahnamon behnamoon.mahsa870@gmail.com 100319475328460012082 100319475328460012082 No Department of Cardiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Roghaiyeh Afsargharehbagh aram.janfaza71@gmail.com 100319475328460012083 100319475328460012083 No Department of Exercise Physiology and Corrective Exercises, Faculty of Sports Sciences, Urmia University, Urmia, Iran.