en انگل شناسي Parasitology پژوهشي Research <div style="text-align: justify;"><strong>Background: </strong>Hydatidosis is known as one of the most prevalent zoonotic diseases across the world. This complication is also endemic in Iran, followed by a higher risk of infection in rural areas. To our knowledge, there has been no study on the seroprevalence of hydatidosis in Sistan and Baluchistan Province, Southeast of Iran. The main objective of the current study was to examine the seroprevalence of hydatidosis and its risk factors in high-risk individuals (farmers and ranchers) living in Sistan and Baluchistan Province.<br> <strong>Materials and Methods:</strong> This study included 500 serum samples, and the participants were requested to complete a researcher-made questionnaire. Subsequently, counter-current immunoelectrophoresis (CCIEP) and enzyme-linked immunosorbent assay (ELISA) methods were employed to analyze the anti-Echinococcus granulosus antibody. The analysis of the obtained data was conducted by logistic regression in SPSS software, version 22.<br> <strong>Results: </strong>According to the results, four (0.8%) cases were found positive for anti-<em>E. granulosus</em> antibody by both CCIEP and ELISA tests. Seroprevalence of hydatidosis was more in rural people, compared to those in urban areas. It was also higher in illiterate people than in educated<br> people. Nevertheless, seropositivity showed no significant differences with age, gender, occupational status, education level, place of residence, and contact with dogs (P>0.05).<br> <strong>Conclusion: </strong>The prevalence rate of hydatidosis in Sistan and Baluchistan Province was similar to that in neighboring provinces. According to the findings, high-risk individuals offer remarkable information about the epidemiology of hydatidosis in Sistan and Baluchistan province in southeastern Iran. This could help to manage and prevent this infection.</div> Echinococcus granulosus, CCIEP, ELISA, Hydatid cyst, Sistan and Baluchestan 27 36 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1225-2&slc_lang=en&sid=1 Davood Anvari davood_anvari@live.com 1 100319475328460010957 No Student Research Committee, Mazandaran University of Medical Science, Sari, Iran.Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Department of Parasitology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. Seyed Abdollah Hosseini hosseini4030@gmail.com 2 100319475328460010958 No Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Ahmad Daryani daryanii@yahoo.com 3 100319475328460010959 No Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Shahabeddin Sarvi shahabesarvi@yahoo.com 4 100319475328460010960 No Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Adel Spotin adelespotin@gmail.com 5 100319475328460010961 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Sanaz Vaziri Shahraki v.shahraki91@gmail.com 6 100319475328460010962 No Department of Parasitology Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran. Mohammad Kalkali mohammad.kalkali1370@gmail.com 7 100319475328460010963 No Department of Parasitology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. Abolghasem Siyadatpanah asiyadatpanah@yahoo.com 8 100319475328460010964 No Ferdows Paramedical School, Birjand University of Medical Sciences, Birjand, Iran Shirzad Gholami sgholami200@gmail.com 9 100319475328460010965 Yes Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.