en ميکروبيولوژي Microbiology پژوهشي Research <div style="text-align: justify;"><strong>Background:</strong> Environmental factors may play a role in colon cancer. In this view, several studies investigated tumor samples for the presence of various viral DNA with conflicting results. The purpose of this study is to investigate the prevalence of Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) in patients with colorectal carcinomas.</div> <div style="text-align: justify;"><strong>Materials and Methods:</strong> In this study, we collected 74 tumorous paraffin-embedded tissues (Mean&plusmn;SD age: 66.3&plusmn;14.98) from the Pathology Department of a hospital in AinTemouchent and laboratories of pathological anatomy in western Algeria. DNA from each tissue was extracted and the presence of HPV and EBV was investigated using PCR.</div> <div style="text-align: justify;"><strong>Results: </strong>None of our samples were HPV or EBV positive, and we failed to find an obvious correlation between EBV and HPV infections and this type of cancer.</div> <div style="text-align: justify;"><strong>Conclusion: </strong>The results suggested that EBV and HPV infection is not common in patients with colorectal cancer in our population. However, the findings merit more investigations on a large number of cases.</div> Human papillomavirus, Epstein–Barr virus , colorectal cancer, Algeria,pcr. 1 8 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1236-1&slc_lang=en&sid=1 Dahmani Bouchra bouchradah@yahoo.com 100319475328460010949 100319475328460010949 Yes Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria. Boublenza Lamia boublenzalamia@gmail.com 100319475328460010950 100319475328460010950 No Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria. Behar Dalale dalale.behar@univ-tlemcen.dz 100319475328460010951 100319475328460010951 No Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria. belatbi Belkacem kassoubel@yahoo.com 100319475328460010952 100319475328460010952 No Department of Pathological Anatomy, Popular Hospital Establishment of Dr. Benzardjeb, Ain Tmouchent, Algeria. Breik Ikram ikrambreik1906@gmail.com 100319475328460010953 100319475328460010953 No Department of Pathological Anatomy, Popular Hospital Establishment of Dr. Benzardjeb, Ain Tmouchent, Algeria. Benfoula Amel brbenfoula@gmail.com 100319475328460010954 100319475328460010954 No Department of Pathological Anatomy, Popular Hospital Establishment of Dr. Benzardjeb, Ain Tmouchent, Algeria. Chabni Nafissa chabni.nafissa@gmail.com 100319475328460010955 100319475328460010955 No Department of Epidemiology, Dr. Tidjani Damerdji University Hospital, Tlemcen, Algeria. Hassaine Hafida h_hassaine@yahoo.fr 100319475328460010956 100319475328460010956 No Department of Natural Sciences of Life, Earth and Universe, Faculty of Biology, University of Abou Bekr Belkaid, Tlemcen, Algeria.