Research in Molecular Medicine

en Decreased Gene Expression of Lipoxin A4 Receptor May Contribute to Nonallergic Rhinitis Pathogenesis ايمونولوژي Immunology پژوهشي Research <div style="text-align: justify;">Background: Rhinitis is a prevalent chronic inflammatory illness of the nasal mucosa. Arachidonic acid-derived lipoxin A4 (LXA4) has long been recognized to exert crucial antiinflammatory and pro-resolving effects on inflammatory responses through a specific receptor named LXA4 receptor/formyl peptide receptor-2 (ALX/FPR2). This study aimed to determine the serum level of LXA4 and the relative mRNA expression level of FPR2 in peripheral blood cells of patients with rhinitis (allergic and nonallergic) compared to healthy individuals.</div> <div style="text-align: justify;">Materials And Methods: The study groups consisted of 37 patients with Allergic Rhinitis (AR), 16 patients with Nonallergic Rhinitis (NAR), and 20 sex- and age-matched healthy individuals. The measurement of LXA4 serum level was performed by the Enzyme-Linked Immunosorbent Assay (ELISA) technique, and the analysis of FPR2 mRNA expression level was performed by quantitative real-time PCR method. Results: The serum concentrations of LXA4 decreased in AR and NAR patients compared to healthy controls; however, this difference was not statistically significant (P>0.05). Besides, the mRNA expression level of FPR2 in peripheral blood cells of patients with nonallergic rhinitis was significantly lower than that in allergic rhinitis (P<0.05).</div> <div style="text-align: justify;">Conclusion: Our results suggest that reduced gene expression of FPR2 may contribute to developing persistent and chronic nasal mucosa inflammation seen in NAR patients. Therefore, stable analogs of LXA4 and its receptor agonist may help develop new therapeutic approaches for rhinitis.</div> Allergic rhinitis, Inflammation, Omega-6 fatty acid, Lipoxin A4, Formyl peptide receptor-2 155 162 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1210-1&slc_lang=en&sid=1 Samira Jahangiri sj6570@yahoo.com 100319475328460010869 100319475328460010869 No Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Ramin Lotfi ramin.lotfi1370@gmail.com 3720269175 100319475328460010870 No Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Seyed Hamidreza Mortazavi dr_mormd@yahoo.com 100319475328460010871 100319475328460010871 No Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Ali Gorgin karaji ali4459@gmail.com 100319475328460010872 100319475328460010872 No Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Alireza Rezaiemanesh alirezarezaeimanesh@gmail.com 100319475328460010873 100319475328460010873 No Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Hatam Rashidpour rashidpourh@gmail.com 100319475328460010874 100319475328460010874 No Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Farhad Salari f.salari@kums.ac.ir 100319475328460010875 100319475328460010875 Yes Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran