en ژنتیک Genetic پژوهشي Research <div style="text-align: justify;"><strong>Background: </strong>Gastric cancer is one of the most common malignancies in the world. It may result from a defect in the genes involved in DNA repair. One of the essential genes in the repair pathway is the XRCC1 gene that its polymorphisms in the human population play a role in gastric cancer susceptibility. The main purpose of this study was to investigate the association of 194C/T and 399G/A polymorphisms of the XRCC1 gene with gastric cancer in an Iranian population.<br> <strong>Materials and methods: </strong>A total of 66 patients with gastric cancer and 67 control individuals were enrolled in our study. Following DNA extraction from blood samples, polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.<br> <strong>Results: </strong>The allele frequencies of C/T of XRCC1-194C/T in the control and patients groups were 83.17% and 71.29%, respectively. Moreover, The allele frequencies of G/A of XRCC1-399G/A in control and patient groups were 66.34% and 62.38%, respectively. Our results indicated a significant positive association between the distribution T/C alleles and the risk of gastric cancer (&chi;2: 5.37 and P=0.02), but no significant association was found in the distribution G/A alleles (&chi;2: 0.47 and P=0.48).<br> <strong>Conclusion: </strong>Altogether, these findings indicate a positive association between the distribution of 194T/C alleles of XRCC1 and the risk of gastric cancer and the presence of the C allele may increase the risk of gastric cancer.</div> PCR, RFLP, SNP, potential markers, DNA repair 171 178 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1050-3&slc_lang=en&sid=1 Jafar Vatandoost j.vatan@hsu.ac.ir 10031947532846009142 10031947532846009142 Yes Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran. Maryam Sanaie j.vatan@hsu.ac.ir 10031947532846009143 10031947532846009143 No Medical Biology Research Center, Health Technology Institute Kermanshah University of Medical Science, Kermanshah, Iran. Kheirollah Yari kyari@kums.ac.ir 10031947532846009144 10031947532846009144 No Zagros Bioidea Co., Razi University Incubator, Kermanshah, Iran