en آسم و آلرژی کودکان Pediatric Allergies and Asthma پژوهشي Research <div style="text-align: justify;"><strong>Background: </strong>In addition to cellular and molecular mechanisms involved in the pathogenesis of asthma, mounting evidences demonstrate that single nucleotide polymorphisms (SNPs) in asthma relevant genes have a role in conferring susceptibility to the disease. CHI3L1 is secreted from macrophages, neutrophils, and airway epithelial cells through an IL-13 related mechanism and contributes to tissue remodeling during asthma.<strong> </strong>Aim of study was to investigate the possible association of rs4950928 SNP in <em>Chiti3L1</em> gene with predisposition to allergic asthma in Iranian Northwestern Azeri population.<br> <strong>Materials and methods:</strong> Frequency of genotypes and alleles of rs4950928 SNP in Chiti3L1 gene was determined using TaqMan genotyping method in 190 patients with asthma and 190 healthy controls.<br> <strong>Results</strong>: Genotype analyzing showed that CC genotype is more frequent (68.4%) among case group vs 57.9% in control group while GG genotype is more abundant (7.9%) among control group vs 3.2% in case group. Furthermore, according to odds ratio (case/ control = 0.611), C allele could be the risk allele whereas G allele can be considered as the protective allele.<br> <strong>Conclusion: </strong>There is a significant relationship between CHI3L1 rs4950928 (-131 C/G) polymorphism and asthma in studied population (P=0.038, <0.05). Patients with asthma were mostly found to have C allele whereas most of the healthy individuals had G allele in their genotype.</div> Asthma, Chit3l1, rs4950928, SNP, YKL-39 17 24 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1124-1&slc_lang=en&sid=1 Daniel Elieh Ali Komi daniel.elieh.mcbiology@gmail.com 10031947532846008520 10031947532846008520 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Mahnaz Sadeghi-Shabestari drsadeghim2004@yahoo.com 10031947532846008521 10031947532846008521 No Children’s hospital, Tabriz University of Medical Sciences, Tabriz, Iran Dariush Shanebandi dariush_shanehbandi@yahoo.com 10031947532846008522 10031947532846008522 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Zohreh Babaloo zbabaloo@tbzmed.ac.ir 10031947532846008523 10031947532846008523 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Alireza Razavi razavial@tums.ac.ir 10031947532846008524 10031947532846008524 No Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Saeed Sadigh-Eteghad saeed.sadigetegad@gmail.com 10031947532846008525 10031947532846008525 No Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran Tohid Kazemi kazemit@tbzmed.ac.ir 10031947532846008526 10031947532846008526 Yes Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran