Research in Molecular Medicine

en Prevalence and clinical symptoms of Human Parainfluenza and Influenza infections in patients admitted to Mazandaran province health centers, 2019 ويروس شناسي پزشکي Medical Virology پژوهشي Research <div style="text-align: justify;">Backgrounds: The human Parainfluenza and Influenza viruses are common causes of respiratory infections in humans. The main goals of this study was investigating the prevalence of these viruses in health centers of Mazandaran province and comparing the clinical manifestations. Materials and methods: The sample collection was done using Dacron swabs from the oropharynx of the patients, and the specimens were transferred to laboratory by Hanks medium. The Viral genomes were isolated by the extraction kits and the RT-PCR and Real time-PCR methods were used for detection of Influenza and Parainfluenza viruses’ prevalence in the specimens, respectively. Results: Out of 100 samples, 5 (5%) specimens were positive for HPIV and 24 (24%) samples were detected as Influenza virus containing specimens. Among the all patients, 50 (50%) of them were female. No HPIV positive patients had croup. While any significant correlation was detected between personality characteristics (sex and age) and the infection with Parainfluenza viruses, but there was a significant relationship between sex and the detection of Influenza virus (p-value <0.05). Moreover, there was a significant relationship between some symptoms like pain and fever with the presence of Influenza virus and the symptoms such as fever and runny nose with the positive results for Parainfluenza in the clinical samples (p-value <0.05). Conclusions: The results of the study revealed the high prevalence of Influenza disease in this region, indicating the necessity of an appropriate plan for the prevention and control using diagnostic tests like PCR.</div> Influenza,HPIV,Real time-PCR,Respiratory infection 29 38 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1122-1&slc_lang=en&sid=1 zeinab Daneshyar saradaneshyar72@gmail.com 10031947532846008553 10031947532846008553 Yes Department of Microbiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hamid reza Goli goli59@gmail.com 10031947532846008554 10031947532846008554 No Department of Microbiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Bahman Mirzaei 10031947532846008555 10031947532846008555 No Department of Medical Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Mehdi Rabie mehdi.rb360@gmail.com 10031947532846008556 10031947532846008556 No Department of Microbiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohammad reza Haghshenas haghshenas 2001@yahoo.com 10031947532846008557 10031947532846008557 No Department of Microbiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran