en ژنتیک Genetic پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: Prostate cancer is the second most prevalent cancer among men all over the world. Over the past 10 years, prostate cancer prevalence has increased in Iran. Growth factors have an important role in the regulation and growth of malignant and normal prostate cells. Therefore, the purpose of this investigation is to examine the association of the expression profile of <em>IGF1</em>, <em>EGF</em>, and <em>FGF2</em> with prostate cancer in an Iranian male population.</div> <div style="text-align: justify;"><strong>Materials and</strong> <strong>methods</strong>: In this investigation, the quantitative real-time RT-PCR technique was applied to evaluate the expression profiles of <em>IGF</em>, <em>EGF</em>, and <em>FGF2</em> in the peripheral blood samples of 40 patients with prostate cancer and 40 healthy individuals. Moreover, the relative expressions of <em>IGF1</em>, <em>EGF</em>, and <em>FGF2</em> in various stages of disease were evaluated.<br> <strong>Results:</strong> Our obtained data indicated a significant increase in the expression of <em>EGF </em>and <em>FGF2</em> in patients with prostate cancer compared with the healthy subjects (P = 0.02 and P = 0.009, respectively). In contrast, the expression level of <em>IGF1</em> was not significantly different between the patients and controls (P = 0.052), but the expression level of <em>IGF1</em> was lower in the patients&#39; group. Additionally, it has been observed that <em>IGF1</em>, <em>EGF</em>, and <em>FGF2</em> expression were directly associated with the stage of disease.<br> <strong>Conclusions:</strong> Our results suggest that <em>EGF</em> and <em>FGF2</em> probably have important role in prostate cancer and were consistent with what had previously been reported. On the other hand, our data revealed no association between the expression of <em>IGF1</em> and prostate cancer in the population studied.</div> EGF, FGF2, IGF1, Prostate cancer 39 44 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1114-1&slc_lang=en&sid=1 Farinaz Khosravian fkhosravian14@gmail.com 10031947532846008583 10031947532846008583 Yes Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Fatemeh Ketabchi f.ketabchi1@yahoo.com 10031947532846008584 10031947532846008584 No Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Nasrin Hadi nasrinhadi90@gmail.com 10031947532846008585 10031947532846008585 No Medical Genetics Research Center of Genome, Isfahan University of Medical Sciences, Isfahan, Iran. Faezeh Namazi faezehnamazi@yahoo.com 10031947532846008586 10031947532846008586 No Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran. Mansoor Salehi M_salehi@med.mui.ac.ir 10031947532846008587 10031947532846008587 No Medical Genetics Research Center of Genome, Isfahan University of Medical Sciences, Isfahan, Iran.