Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1396
5
1
gregorian
2017
8
1
5
3
online
1
fulltext
en
A report on Allelic Variation in Helicobacter pylori dupA: A viewpoint
عفوني
Infectious Diseases
review
review
<div style="text-align: justify;"><em>Helicobacter pylori (H. pylori</em>) is the pivotal cause of chronic gastritis, peptic ulcer diseases (PUD) and gastric cancer. Morphologically, the bacterium is spiral, Gram-negative and microaerophilic which survives lifespan in the human stomach in case of weak antibiotic therapy. There is a major difference in the pattern of global prevalence of <em>H. pylori </em>infection based on different levels of urbanization, hygiene, sanitation, access to clean water and other socioeconomic factors. To date, many studies have attempted to find significant associations between specific gastroduodenal diseases and <em>dupA</em>-positive strains, but no conclusive conclusion has been declared. The main reason for these inconsistent findings is the various methodologies applied in experiments which in turn have resulted in inaccurate observation. Our analysis showed that the existence of various alleles located in the <em>dupA</em> cluster would be a novel explanation for different associations found between this bacterial gene and diseases. In detailed experiments examining our proposed alleles using a large number of patients can be useful to disclose a significant clinical association between <em>H. pylori dupA</em>-positive strains and duodenal ulcer.<br>
</div>
Helicobacter pylori, dupA, duodenal ulcer, allelic variation
1
4
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-851-4&slc_lang=en&sid=1
Golzar
Fatahi
golzar.fatahi@gmail.com
10031947532846006760
10031947532846006760
No
Tarbiat Modares University, Dept of Bacteriology, P.O. Box: 14115-111, Tehran, Iran
Amin
Talebi Bezmin Abadi
Amin
Talebi Bezmin Abadi
amin.talebi@modares.ac.ir
10031947532846006761
10031947532846006761
Yes
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Tarbiat Modares University, Dept of Bacteriology, P.O. Box: 14115-111, Tehran, Iran