en ژنتیک Genetic پژوهشي Research <p style="text-align: justify;"><strong>Background: </strong>Bladder cancer (BC) is the most commonly diagnosed genitourinary cancer in Iran, presented in both men and women. BC is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. Long stress-induced non-coding transcript 5 (LSINCT5), a member of the long non-coding RNAs, is abundantly expressed in high proliferative cells, as well as the cells vulnerable to cellular stress in response to chemical carcinogens.</p> <p style="text-align: justify;">This case-control study aimed to determine any association between LSINCT5 rs2962586 polymorphism and bladder cancer.</p> <p style="text-align: justify;"><strong>Materials and Methods</strong>: A group of 150 patients with BC were compared with 143 subjects as a control group. Genotyping of the rs2962586 polymorphism was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR) method.</p> <p style="text-align: justify;"><strong>Results: </strong>Genotype and allele distribution were not significantly different between the case and control groups. Smoking was found to be the confounding risk factor for bladder cancer.</p> <p style="text-align: justify;"><strong>Conclusion: </strong>Considering the result of our analyses, it seems that LSINCT5 could not affect individual susceptibility to BC among Iranian patients, however, it can be considered as a disease predictor among smokers.</p> Bladder cancer, Long stress induced non-coding transcript 5, Polymorphism 17 21 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-689-3&slc_lang=en&sid=1 Mahla Nazari nazari.mahla1368@gmail.com 10031947532846005358 10031947532846005358 No Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran Mahboobeh Nasiri nasiri@iaua.ac.ir 10031947532846005359 10031947532846005359 Yes Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran Abbas Ghaderi 10031947532846005360 10031947532846005360 No Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran