en ميکروبيولوژي Microbiology پژوهشي Research <p><strong>Background</strong><strong>:</strong> In this study we aimed at detecting the enterotoxin A and B gene of <em>S. aureus</em> in clinical samples of patients attending health centers in Zahedan using molecular methods.</p> <p><strong>Materials and Methods: </strong>A cross-sectional study was carried out in which 40 samples of <em>S. aureus</em> were obtained from patients in a hospital in Zahedan, Iran. Following the biochemical tests, Identifications were confirmed by PCR with specific primers.</p> <p><strong>Results:</strong> Among 40 clinical isolates of <em>S. aureus</em> the frequency of sea gene was 2% and the frequency of seb gene was 8% while the frequency of both sea+seb genes was 3%.</p> <p><strong>Conclusion:</strong> Enterotoxin of <em>S. aureus</em> is one of the main factors in the pathogenesis of various diseases and production of these toxins increase the incidence of diseases, so rapid treatment is needed for enterotoxin gene expression.</p> <p dir="ltr" style="text-align: justify;"></p> Enterotoxin, Food Poisoning, Staphylococcus aureus, Gene 44 46 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-812-1&slc_lang=en&sid=1 Mohammad Bokaeian mbokae@yahoo.com 10031947532846005141 10031947532846005141 No 1. Infectious Disease and Tropical Medicine Research Center Zahedan University of Medical Sciences Saeide Saeidi s.saeedi12@yahoo.com 10031947532846005142 10031947532846005142 No 2. Institute of Plant Biotechnology, University of Zabol, 98616, Iran Mehdi Hassanshahian hasanshahi@gmail.com 10031947532846005143 10031947532846005143 Yes : Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.