en ايمونولوژي Immunology review review <p>ABO blood type antigens are polymorphic, inherited structures presented on the surface of red blood cells. Although ABO blood group antigens is the most important antigens in transfusion medicine, its main role is not clearly clarified. Correlation between ABO blood group and susceptibility to certain infectious and non-infectious diseases is a controversial issue. Since, lack of blood type antigens has not been related to significant diseases or health risks. There are many research studies that suffice to prove that blood antigens are biologically active, carbohydrate structures involving to the &ldquo;cell physiology and human pathology&rdquo;. This review summarizes the available data concerning the blood group antigens correlation with different aspects of health. We therefore investigated that certain blood type antigens can affect susceptibility to diseases or make a phenotype resistant.</p> Blood groups, ABO, Cancers, Cardiovascular disease, Infectious disease, Human health 1 9 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-615-10&slc_lang=en&sid=1 Omolbanin Amjadi prs.amjadi0o0@gmail.com 10031947532846007043 10031947532846007043 No Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Alireza Rafiei rafiei1710@gmail.com 10031947532846007044 10031947532846007044 Yes Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Abolghasem Ajami a.ajami36@gmail.com 10031947532846007045 10031947532846007045 No Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Reza Valadan valadan.reza@gmail.com 10031947532846007046 10031947532846007046 No Molecular and Cell Biology Research Center, Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Ghasem Janbaabaei janbabai@yahoo.com 10031947532846007047 10031947532846007047 No Cancer Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran