Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1394
8
1
gregorian
2015
11
1
3
4
online
1
fulltext
en
Association of Uric Acid with Antioxidant Capacity of Plasma in Patients with Type 2 Diabetic Nephropathy
بیوشیمی
Biochemistry
پژوهشي
Research
<p dir="ltr" style="text-align: justify"><strong>Background:</strong> The role of attenuation in antioxidant capacity or expansion of pro-oxidant/oxidant is well known for the development of stress oxidative. The aim of this study was to evaluate the plasma antioxidant capacity along with uric acid in patients with diabetic nephropathy (DN+) and without diabetic nephropathy (DN-).</p>
<p dir="ltr" style="text-align: justify"><strong>Materials and Methods: </strong>The research population included 88 patients with DN, 66 patients without DN and 54 healthy people who were matched for age, gender, and body mass index (BMI). In all groups, total antioxidant capacity of plasma by the ferric reducing antioxidant power (FRAP) assay and serum uric acid by commercial kit, respectively.</p>
<p dir="ltr" style="text-align: justify"><strong>Results:</strong> The mean age of patients in DN+, DN- and control groups were 59.3± 9.4, 60 ±11.2, and 54.6±6.9 years, respectively. Plasma antioxidant capacity was higher in patients with DN+, (1589±330&mu mol/l Fe2+) and DN- (1344± 347 &mu mol/l Fe2+) than that in healthy controls (1187±271 &mu mol/l Fe2+ ) (P<0.001). The mean plasma uric acid in patients with DN+ was significantly higher (8.7±1.3 mg/dl) compared with DN- (7.3±1.2 mg/dl) (P<0.01), and significantly lower in control group (4.1±1.4 mg/dl) (P<0.001).</p>
<p dir="ltr" style="text-align: justify"><strong>Conclusion: </strong>According to our results, despite innate antioxidant activity of uric acid and increase of total antioxidant capacity and concentration of uric acid in diabetic patients with or without nephropathy, it cannot compensates the severity of oxidative stress. Further studies are required to determine the value of other antioxidant factors in increasing the power of total antioxidant capacity.</p>
Diabetes Mellitus,Nephropathy, Antioxidant, Uric acid
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http://rmm.mazums.ac.ir/browse.php?a_code=A-10-233-1&slc_lang=en&sid=1
Vahid
Ansari
vahid.msc.91@gmail.com
10031947532846007056
10031947532846007056
No
Department of Biochemistry, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
Mehryar
Zargari
zargari.mehryar@gmail.com
10031947532846007057
10031947532846007057
Yes
Department of Biochemistry, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
Ateih
Makhlough
makhloguh_a@yahoo.com>
10031947532846007058
10031947532846007058
No
Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
Shiva Saddat
Mirabedini
shiva.mirabedini@live.com
10031947532846007059
10031947532846007059
No
Department of Biochemistry, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
Samineh
Motallebi-Reikandeh
sam.biology.2012@gmail.com
10031947532846007060
10031947532846007060
No
Dokht Iran, high school, education office district 2, Sari, Iran