en زیست شناسی مولکولی Molecular biology review review <p>MPNs including a heterogeneous group of clonal or oligoclonal hamtopathies characterized by proliferation and accumulation of mature myeloid cells. JAK2 tyrosine kinase mutation is the most common molecular lesion identified in 90% of cases. JAK2 is involved in EPO signaling pathway, and mutations in it lead to EPO-independent spontaneous phosphorylation. Most tyrosine kinase inhibitors (TKI) are small molecules that compete with ATP for binding the ATP-binding site in tyrosine kinase domains, since ATP is a source of phosphate groups used by Tks to phosphorylate the target protein.there are many TKI agent that are studing for treatment of the MPNs with JAK2 tyrosine kinase mutation.the most important TKI drugs including CEP701, CYT387, LY2784544, SB1518, TG101348, XL019, INCB18424. Most important mechanism of them are reduse the splenomegaly, improvement of constitutional symptoms(improvement of bone marrow fibrosis and anemia). Although this drugs are useful but they have some side effect that common of them including Gastrointestinal disease (GI), diarrhea, nausea and vomiting, anemia, thrombocytopenia, thrombosis, leukocytosis, thrombocytosis, peripheral neuropathy, transient loss of blood pressure and lightheadedness.</p> MPN, JAK2, TKI 1 10 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-678-4&slc_lang=en&sid=1 Kaveh Tari k.tari@modares.ac.ir 10031947532846005650 10031947532846005650 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Amir Atashi a@yahoo.com 10031947532846005651 10031947532846005651 Yes Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Reza Yarahmadi 10031947532846005652 10031947532846005652 No Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran Saeid Abroun 10031947532846005653 10031947532846005653 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Abbas Hajifathali 10031947532846005654 10031947532846005654 No Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeid Kaviani 10031947532846005655 10031947532846005655 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Masoud Soleimani 10031947532846005656 10031947532846005656 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran