en ژنتیک Genetic پژوهشي Research <p><b>Bachground: </b>Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Iranian population.<br> <b>Materials and Methods: </b>This case-control study was performed on 100 endometriosis patients and 100 healthy individuals. The IL-8 -251T/A genotypes were determined using PCR-RFLP method. The association between genotypes of the -251T/A polymorphism and the endometriosis risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs).<br> <b>Results:</b> No statistically significant associations were observed between IL-8 -251 variants and the risk of endometriosis development (&chi2: 1.02, P: 0.63). In addition, subgroup analysis according to severity of disease, were unable to identify any association between IL-8 -251T/A polymorphism and endometriosis (P>0.05), and there was no significant association between IL-8 -251T/A and the severity of endometriosis.<br> <b>Conclusions:</b> This is the first study regard to association of -251T/A polymorphism with endometriosis risk. Our results indicate that the presence of the -251T/A polymorphism in IL-8 gene is not associated with the risk of endometriosis.</p> endometriosis, Interleukin-8, Iranian population, polymorphism 45 49 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-739-1&slc_lang=en&sid=1 Farnoosh Rabbanizadeh farnoosh.rabbanizadeh@gmail.com 10031947532846004034 10031947532846004034 No Department of Biology, College of Sciences, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran leila kohan kohan@iaua.ac.ir 10031947532846004035 10031947532846004035 Yes Department of Biology, College of Sciences, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran Fatemesadat Najib Najibf@sums.ac.ir 10031947532846004036 10031947532846004036 No Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran