Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1394
5
1
gregorian
2015
8
1
3
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online
1
fulltext
en
Is Quantitative HBsAg Measurement a Reliable Substitute for HBV DNA Quantitation?
ويروس شناسي پزشکي
Medical Virology
پژوهشي
Research
<p><strong>Background: </strong>Hepatitis B surface antigen (HBsAg) is one of the main proteins of HBV envelop and its serum quantitative measurement is the most common quantitative test for monitoring the progress of Chronic Hepatitis B. Although measurement of serum HBV DNA copy number is a gold standard method for displaying viral load, the test is relatively expensive and it is not readily available everywhere in the world, while quantitative detection of HBsAg is fairly easy and inexpensive. The aim of this study was to investigate the correlation between serum HBsAg level and HBV DNA copy number in patients with chronic HB.<br>
<strong>Materials and Methods: </strong>Quantitative HBsAg, quantitative HBV DNA, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels were tested in 74 patients with chronic hepatitis B infection - who were HBsAg-positive for more than 6 months. In order to find any correlation between the results of these methods, Spearman and Kruska-Wallis correlation coefficient tests were applied.<br>
<strong>Results:</strong> No significant correlation was observed between quantitative HBsAg and HBV DNA measurements. Also, we could not find any correlation between serum HBsAg and ALT levels. But, serum HBV DNA content and AST level had a significant positive correlation.<br>
<strong>Conclusion: </strong>There are many factors affecting the correlation between serum HBV DNA copy number and HBsAg level such as genotype of HBV virus, phase of infection, methods of measurement, HBeAg status, and drug and types of treatment procedures. Therefore, these factors should be considered in further studies dealing with the correlation between quantitative HBV DNA and HBsAg tests.</p>
Quantitative HBsAg, HBV DNA, Chronic hepatitis B
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http://rmm.mazums.ac.ir/browse.php?a_code=A-10-732-1&slc_lang=en&sid=1
Mohammad Reza
Mahdavi
mahdavi899@gmail.com
10031947532846004075
10031947532846004075
Yes
Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
Mohammad Reza
Haghshenas
Haghshenas.m@yahoo.com
10031947532846004076
10031947532846004076
No
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari,Iran
Payam
Roshan
Payam.roshan@gmail.com
10031947532846004077
10031947532846004077
No
Sina Mehr Research Center, Sari, Iran
Mohammad Taher
Hojjati
Hojati.m.t@gmail.com
10031947532846004078
10031947532846004078
No
Sina Mehr Research Center, Sari, Iran
Mehrad
Mahdavi
info@fajrlaboratory.com
10031947532846004079
10031947532846004079
No
Sina Mehr Research Center, Sari, Iran
Hossein
Jalali
Hossein.jalaliakerdi@gmail.com
10031947532846004080
10031947532846004080
No
Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
Aily
Aliasgharian
bahare92@gmail.com
10031947532846004081
10031947532846004081
No
Thalassemia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran