Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1393
8
1
gregorian
2014
11
1
2
4
online
1
fulltext
en
Association between Epstein - Barr Virus (EBV) and Breast Cancer
آسيب شناسي
Pathology
پژوهشي
Research
<p><strong>Background: </strong>Breast cancer is the most common malignancy in females worldwide. Several etiological factors including environmental factors have been recognized for breast cancer. Epstein Barr virus as a viral etiological factor has been proposed. So far, several studies have investigated the relationship between development of breast cancer and <i>Epstein Barr virus</i>, but few have been done in Iran. The aim of this study was to determine whether there was an association between EBV infection and female breast cancer in Iran.<strong> </strong></p>
<p><strong>Materials and Methods:</strong> We analyzed paraffin embedded breast tissue specimens by polymerase chain reaction (PCR) including breast cancer specimens (as case group) and breast fibroadenoma specimens (as control group). PCR was performed to amplify specific sequences of EBV.</p>
<p><strong>Results:</strong> From 130 cases of breast samples, 67 cases of breast cancer tissues and 41 cases of breast fibroadenoma tissues had adequate quality and quantity of DNA to detect EBV. PCR for EBV was positive in 4 invasive ductal carcinoma specimens (7.3%) and only one of the fibroadenoma specimens (2.4%). No significant association was found between EBV infection and invasive ductal carcinoma (p> 0.05). Also, patient’s age and histological grade of IDC were not correlated with EBV infection (p>0.05).</p>
<p><strong>Conclusion</strong>: We observed no etiologic association between EBV infection and invasive ductal carcinoma of female breast in our regions however, further studies are required to elucidate this association .</p>
<p></p>
Breast cancer, Fibroadenoma, Epstein-Barr virus, Polymerase chain reaction
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http://rmm.mazums.ac.ir/browse.php?a_code=A-10-615-9&slc_lang=en&sid=1
Zhila
Torabizadeh
10031947532846006135
10031947532846006135
No
Department of Pathology - - Imam khomeini Hospital Mazandaran University of Medical Sciences Razi St. Sari, Iran I
Alireza
Nadji
10031947532846006136
10031947532846006136
No
Virology research center - - Masih Daneshvari hospital, Shahid Beheshti University of Medical Sciences
Farshad
Naghshvar
10031947532846006137
10031947532846006137
No
Department of Pathology - - Imam khomeini Hospital Mazandaran University of Medical Sciences Razi St. Sari, Iran I
Anahita
Nosrati
Anahita785@gmail.com
10031947532846006138
10031947532846006138
Yes
Department of Pathology - - Imam khomeini Hospital Mazandaran University of Medical Sciences Razi St. Sari, Iran I
Mohsen
Parsa
10031947532846006139
10031947532846006139
No
Department of Pathology - - Imam khomeini Hospital Mazandaran University of Medical Sciences Razi St. Sari, Iran I