en هماتولوژی و آنکولوژی Hematology & Oncology review review <p>Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to 8 subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF), systematic mastositosis (SM), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and unclassified myelofibrosis disorders (UMPN). It usually occurs in 5th to 7th decade of life. However, CNL and ET have been observed in children. A lot of mutations have been identified in these disorders that Jak2V617F is the most important mutation. Moreover, several somatic mutations other than JAK2V617F in MPN patients have been reported. Such mutations include MPL, TET2, ASXL1, IDH1, IDH2, CBL, LNK, IKZF, and EZH2 from precursor stem cells. The role of mutations mentioned is not clear in pathogenesis of this disease. Hence, in this study, mutations in different stages of myeloproliferative disorders have been reviewed.</p> MPN, Hematopoietic stem cells, Mutation 3 11 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-678-1&slc_lang=en&sid=1 Kaveh Tari k.tari@modares.ac.ir 10031947532846006117 10031947532846006117 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Reza Yarahmadi R.yarahmadi@ymail.com 10031947532846006118 10031947532846006118 No Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran Amir Tabatabaei amirtabatabaei60@yahoo.com 10031947532846006119 10031947532846006119 No Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran Fakhredin Saba 10031947532846006120 10031947532846006120 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Saeid Abroun abroun@modares.ac.ir 10031947532846006121 10031947532846006121 Yes Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Amir Atashi atashia@modares.ac.ir 10031947532846006122 10031947532846006122 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Masoud Soleimani soleiman_m@modares.ac.ir 10031947532846006123 10031947532846006123 No Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran