TY - JOUR JF - Res-Mol-Med JO - Res Mol Med (RMM) VL - 6 IS - 4 PY - 2018 Y1 - 2018/11/01 TI - Antimicrobial Effect of Multilayered Carbon Nanotubes on Multi-Drug-Resistant Pseudomonas aeruginosa TT - N2 - Background: Pseudomonas aeruginosa is the primary cause of infection with impaired defense mechanisms. P. aeruginosa commonly causes nosocomial infections and is the most common pathogen isolated from patients hospitalized for longer than 1 week. We examined the antimicrobial effect of multilayered carbon nanotubes on multi-drug-resistant. Materials and methods: In this research, 20 clinical isolates collected at Motahari Hospital (Tehran, Iran) were compared with the standard (ATCC 27853) and identified as P. aeruginosa based on biochemical testing. Conventional disk diffusion assay demonstrated the methicillin resistance of the isolates. Minimal inhibitory concentrations for antibiotics and the multilayer CNTs were determined using the microdilution method. Single-walled CNTs were prepared and their efficacy and potential synergism with antibiotics was assessed. Results: Synergism against P. aeruginosa was evident for methicillin + single-walled CNTs. Conclusion: The inhibitory effect of single-walled CNTs and methicillin was synergistic against the growth of P. aeruginosa. SP - 38 EP - 47 AU - Mousavi, Hadis AU - Rouhani nejad, Hamideh AU - Zandi, Masoud AU - Khodavirdipour, Amir AD - Malek-Ashtar University of Technology, Tehran, Iran KW - antimicrobial KW - nanoparticle KW - multilayered carbon nanotubes KW - nanomedicine KW - Pseudomonas aeruginosa UR - http://rmm.mazums.ac.ir/article-1-292-en.html ER -