TY - JOUR JF - Res-Mol-Med JO - Res Mol Med (RMM) VL - 7 IS - 2 PY - 2019 Y1 - 2019/5/01 TI - Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission TT - N2 - Background: Bovine leukaemia virus (BLV) is the cause of enzootic bovine leukaemia which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of virus (BLV) transfer from animal production to humans may exist. Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR. Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples. Conclusion: These findings explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time. SP - 25 EP - 32 AU - Taghadosi, Camellia AU - Kojouri, Gholamali AU - Ahadi, Alimohammad AU - Hashemi Bahremani, Mohammad AU - Kojouri, Abdolnabi AD - Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord university KW - BLV KW - lymphoma KW - nested PCR KW - RT-nested-PCR KW - Tax. UR - http://rmm.mazums.ac.ir/article-1-311-en.html DO - https://doi.org/10.32598/rmm.7.2.75 ER -