AU - Fotoohi, Maryam AU - Hadi, Nasrin AU - Namazi, Faezeh TI - Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma PT - JOURNAL ARTICLE TA - Res-Mol-Med JN - Res-Mol-Med VO - 6 VI - 4 IP - 4 4099 - http://rmm.mazums.ac.ir/article-1-301-en.html 4100 - http://rmm.mazums.ac.ir/article-1-301-en.pdf SO - Res-Mol-Med 4 ABĀ  - Background: The most malignant form of infiltrating astrocytoma, glioblastoma multiforme (GBM), is one of the most aggressive human cancers. Foretinib diminished GBM cell invasion by downregulating the expression of matrix metalloproteinase 2 (MMP2). The study aimed to examine the anti-tumor activity of foretinib and to test its effect on MMP2 expression in T98 cells. Materials and methods: T98 cells were used as an experimental model of glioblastoma. The effect of foretinib on the expression of MMP2 was evaluated using quantitative real-time polymerase chain reaction. Thereafter, the effect of foretinib on the enzyme levels of MMP was examined by zymography. Statistical analyses were performed with GraphPad Prism software. Results: A reduction in the expression of MMP2 was observed with an increase in the concentration of foretinib. Conclusion: Foretinib treatment leads to downregulation of MMP-2 and has a positive effect on T98 cells. We believe that foretinib can be subjected to further clinical investigation to develop a treatment for GBM. CP - IRAN IN - LG - eng PB - Res-Mol-Med PG - 20 PT - Research YR - 2018