دوره 1، شماره 3 - ( پائيز 1392 )                   جلد 1 شماره 3 صفحات 29-33 | برگشت به فهرست نسخه ها




DOI: 10.18869/acadpub.rmm.1.3.29

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Qujeq D, Tatar M, Feizi F, Parsian H, Halalkhor S. Effect of Teucrium polium leaf extracts on AMPK level in Isolated Rat Pancreases. Res Mol Med (RMM). 2013; 1 (3) :29-33
URL: http://rmm.mazums.ac.ir/article-1-53-fa.html
Effect of Teucrium polium leaf extracts on AMPK level in Isolated Rat Pancreases. Research in Molecular Medicine. 1392; 1 (3) :29-33

URL: http://rmm.mazums.ac.ir/article-1-53-fa.html


چکیده:   (19800 مشاهده)

Background: The purpose of this study is to evaluate effects of Teucrium polium (TP) leaf extracts on adenosine monophosphate activated protein kinase (AMPK) level in isolated pancreases.
Materials and Methods: In this experimental study, two groups of rats were used as a control group, and diabetic group. In the end of experimental period the animals were sacrificed then pancreas were removed, then isolated rat pancreas was cultured in buffer with or without TP leaf extracts. Measuring the sample glucose level was carried out by spectrophotometric method ( Jenway ,Model 6505 ,UK, Pars Azmmon Co. ,Tehran, IRAN) . Insulin level was assayed by an enzyme immunoassay ELISA kit specific for rats made by Mercodia Rat insulin ELISA ( 10-1250-01,Mercodia AB, Uppsala, Sweden). The adenosine monophosphate activated protein kinase level was determined by ELISA assay method using a rat phosphorylated AMPK ELISA kit ( CSB-E11337r, Cusabio Biotech Co .,LTD).
Results: The results indicate that addition of TP leaf extract significantly increased AMPK level and insulin content compared to untreated group (p<0.05).
Conclusion: These results support the potential of TP leaf extract as a therapeutic modality for diabetes. However, further studies will be necessary to confirm this potential.

متن کامل [PDF 388 kb]   (897 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: شیمی دارویی
دریافت: ۱۳۹۲/۸/۱۱ | پذیرش: ۱۳۹۲/۱۰/۳ | انتشار: ۱۳۹۲/۱۰/۳

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
کد امنیتی را در کادر بنویسید

کلیه حقوق این وب سایت متعلق به Research in Molecular Medicine می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2015 All Rights Reserved | Research in Molecular Medicine

Designed & Developed by : Yektaweb