Volume 8, Issue 3 (Aug 2020)
Res Mol Med (RMM) 2020, 8(3): 125-132 |
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Obeidi N, Mousavi M J, Hosseinpouri A, Malekhayati H, Ehsandoost E. Anticoagulative Effect of Two Species of Brown Algae; Sargassum Angustifolium and Cystoseira Indica. Res Mol Med (RMM) 2020; 8 (3) :125-132
URL: http://rmm.mazums.ac.ir/article-1-364-en.html
URL: http://rmm.mazums.ac.ir/article-1-364-en.html
Narges Obeidi 
1, Mohammad Javad Mousavi2 , Arghavan Hosseinpouri3 , Hamideh Malekhayati4 , Elham Ehsandoost5
1, Mohammad Javad Mousavi2 , Arghavan Hosseinpouri3 , Hamideh Malekhayati4 , Elham Ehsandoost5
1- Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. , nobeidi@yahoo.com
2- Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
3- Department of Cellular and Molecular Sciences, Faculty of Sciences, Persian Gulf University, Bushehr, Iran.
4- Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran.
5- Department of Food Science & Technology, Shiraz University, Shiraz, Iran.
2- Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
3- Department of Cellular and Molecular Sciences, Faculty of Sciences, Persian Gulf University, Bushehr, Iran.
4- Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran.
5- Department of Food Science & Technology, Shiraz University, Shiraz, Iran.
Abstract: (1906 Views)
Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the present study, we aimed to evaluate the anticoagulative effects of two species of brown algae, namely Sargassum angustifolium (S. angustifolium) and Cystoseira indica (C. indica).
Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively. The anticoagulative effects of fucoidan C and fucoidan S were tested on 10 normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT).
Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S.
Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.
Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively. The anticoagulative effects of fucoidan C and fucoidan S were tested on 10 normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT).
Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S.
Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.
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