Volume 6, Issue 3 (Aug 2018)
Res Mol Med (RMM) 2018, 6(3): 1-19 |
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Sadeghi-Amiri L, Barzegar A, Rafiei A, Amjadi O. An Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis. Res Mol Med (RMM) 2018; 6 (3) :1-19
URL: http://rmm.mazums.ac.ir/article-1-295-en.html
URL: http://rmm.mazums.ac.ir/article-1-295-en.html
1- Department of Basic Sciences, Sari Agriculture Scienceand Natural Resources University, Sari, Iran , alibar647@yahoo.com
2- Department of Basic Sciences, Sari Agriculture Scienceand Natural Resources University, Sari, Iran
3- Department of Immunology, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4- Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
2- Department of Basic Sciences, Sari Agriculture Scienceand Natural Resources University, Sari, Iran
3- Department of Immunology, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4- Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Abstract: (3353 Views)
The five leading causes of cancer-related deaths are lung (1,760,000 deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths), and breast (627,000 deaths) cancers. Epigenetic changes can alter chromatin compaction, leading to the regulation of geneexpression without changing the primary DNA sequence.Epigenetic mechanisms are normally involved incellular processes such asgenomic stability, chromosome X inactivation, and embryonic development and differentiation. Similar to other types of chromatin modifications, DNA methylation has been verifiedto affect the expression of various genes. Any impairment in these mechanisms alters the regulation of gene expression and can contribute to malignant cell transformation. Over the past few years, extensive innovations within the field of epigenetics have encouraged its application as a major strategy for the treatment of important diseases such as cancer.
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