Volume 5, Issue 3 (Aug 2017)                   Res Mol Med (RMM) 2017, 5(3): 1-4 | Back to browse issues page


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Abstract:   (602 Views)
Helicobacter pylori (H. pylori) is the pivotal cause of chronic gastritis, peptic ulcer diseases (PUD) and gastric cancer. Morphologically, the bacterium is spiral, Gram-negative and microaerophilic which survives lifespan in the human stomach in case of weak antibiotic therapy. There is a major difference in the pattern of global prevalence of H. pylori infection based on different levels of urbanization, hygiene, sanitation, access to clean water and other socioeconomic factors. To date, many studies have attempted to find significant associations between specific gastroduodenal diseases and dupA-positive strains, but no conclusive conclusion has been declared. The main reason for these inconsistent findings is the various methodologies applied in experiments which in turn have resulted in inaccurate observation. Our analysis showed that the existence of various alleles located in the dupA cluster would be a novel explanation for different associations found between this bacterial gene and diseases. In detailed experiments examining our proposed alleles using a large number of patients can be useful to disclose a significant clinical association between H. pylori dupA-positive strains and duodenal ulcer.
 
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Type of Study: review | Subject: Infectious Diseases
Received: 2017/12/4 | Accepted: 2018/02/6 | Published: 2018/02/6

References
1. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983; 321(8336):1273-5. PMID: 6134060 [DOI:10.1016/S0140-6736(83)92719-8]
2. Hooi JK, Lai WY, Ng WK, Suen MM, Underwood FE, Tanyingoh D, et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-analysis. Gastroenterology. 2017; 153(2):420-429. PMID: 28456631 [DOI:10.1053/j.gastro.2017.04.022]
3. Leja M, Axon A, Brenner H. Epidemiology of Helicobacter pylori infection. Helicobacter. 2016; 21(S1):3-7. PMID: 27531531 [DOI:10.1111/hel.12332]
4. Abadi ATB, Kusters JG. Management of Helicobacter pylori infections. BMC Gastroenterol. 2016; 16(1):94. PMID: 27520775 [DOI:10.1186/s12876-016-0496-2]
5. Abadi ATB. Strategies used by helicobacter pylori to establish persistent infection. World J Gastroenterol. 2017; 23(16):2870 -2882. PMID: 28522905 [DOI:10.3748/wjg.v23.i16.2870]
6. Lu H, Hsu P-I, Graham DY, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology. 2005; 128(4):833-48. PMID: 15825067 [DOI:10.1053/j.gastro.2005.01.009]
7. Lu H, Yamaoka Y, Graham DY. Helicobacter pylori virulence factors: facts and fantasies. Curr Opin Gastroenterol. 2005; 21(6):653-9. PMID: 16220040 [DOI:10.1097/01.mog.0000181711.04529.d5]
8. Arachchi H, Kalra V, Lal B, Bhatia V, Baba C, Chakravarthy S, et al. Prevalence of Duodenal Ulcer‐Promoting Gene (dupA) of Helicobacter pylori in Patients with Duodenal Ulcer in North Indian Population. Helicobacter. 2007; 12(6):591-7. PMID: 18001398 [DOI:10.1111/j.1523-5378.2007.00557.x]
9. Paredes-Osses E, Saez K, Sanhueza E, Hebel S, Gonzalez C, Briceno C, et al. Association between cagA, vacAi, and dupA genes of Helicobacter pylori and gastroduodenal pathologies in Chilean patients. Folia Microbiol (Praha). 2017; 62(5):437-44. PMID: 28283946 [DOI:10.1007/s12223-017-0514-y]
10. Wang MY, Chen C, Shao C, Wang SB, Wang AC, Yang YC, et al. Intact long-type DupA protein in Helicobacter pylori is an ATPase involved in multifunctional biological activities. Microb Pathog. 2015; 81:53-9. PMID: 25745877 PMID: 25804905 [DOI:10.1016/j.micpath.2015.03.002]
11. Nagashima H, Yamaoka Y. Helicobacter pylori dupA and smoking are associated with increased levels of interleukin-8 in gastric mucosa in Iraq-reply. Hum Pathol. 2015; 46(6):931. [DOI:10.1016/j.humpath.2015.01.022]
12. Salih AM, Goreal A, Hussein NR, Abdullah SM, Hawrami K, Assafi M. The distribution of cagA and dupA genes in Helicobacter pylori strains in Kurdistan region, northern Iraq. Ann Saudi Med. 2013; 33(3):290-3. PMID: 23793434 [DOI:10.5144/0256-4947.2013.290]
13. Queiroz DM, Rocha GA, Rocha AM, Moura SB, Saraiva IE, Gomes LI, et al. dupA polymorphisms and risk of Helicobacter pylori-associated diseases. Int J Med Microbiol. 2011; 301(3):225-8. PMID: 21050811 [DOI:10.1016/j.ijmm.2010.08.019]
14. Queiroz DM, Moura SB, Rocha AM, Costa RF, Anacleto C, Rocha GA. The genotype of the Brazilian dupA-positive Helicobacter pylori strains is dupA1. J Infect Dis. 2011; 203(7):1033-4. PMID: 21402555 [DOI:10.1093/infdis/jiq147]
15. Zhang Z, Zheng Q, Chen X, Xiao S, Liu W, Lu H. The Helicobacter pylori duodenal ulcer promoting gene, dupA in China. BMC Gastroenterol. 2008; 8:49. PMID: 18950522 [DOI:10.1186/1471-230X-8-49]
16. Gomes LI, Rocha GA, Rocha AM, Soares TF, Oliveira CA, Bittencourt PF, et al. Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol. 2008; 298(3-4):223-30. PMID: 17897881 [DOI:10.1016/j.ijmm.2007.05.006]
17. Douraghi M, Mohammadi M, Oghalaie A, Abdirad A, Mohagheghi MA, Hosseini ME, et al. dupA as a risk determinant in Helicobacter pylori infection. J Med Microbiol. 2008; 57(Pt 5):554-62. PMID: 18436587 [DOI:10.1099/jmm.0.47776-0]
18. Arachchi HS, Kalra V, Lal B, Bhatia V, Baba CS, Chakravarthy S, et al. Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter. 2007; 12(6):591-7. PMID: 18001398 [DOI:10.1111/j.1523-5378.2007.00557.x]
19. Talebi Bezmin Abadi A, Perez-Perez G. Role of dupA in virulence of Helicobacter pylori. World J Gastroenterol. 2016; 22(46):10118-23. PMID: 28028359 [DOI:10.3748/wjg.v22.i46.10118]
20. Jung SW, Sugimoto M, Shiota S, Graham DY, Yamaoka Y. The intact dupA cluster is a more reliable Helicobacter pylori virulence marker than dupA alone. Infect Immun. 2012; 80(1):381-7. PMID: 22038914 [DOI:10.1128/IAI.05472-11]
21. Alam J, Maiti S, Ghosh P, De R, Chowdhury A, Das S, et al. Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population. J Med Microbiol. 2012; 61(Pt 9):1295-302. PMID: 22653921 [DOI:10.1099/jmm.0.038398-0]
22. Matteo MJ, Armitano RI, Granados G, Wonaga AD, Sanches C, Olmos M, et al. Helicobacter pylori oipA, vacA and dupA genetic diversity in individual hosts. J Med Microbiol. 2010; 59(Pt 1):89-95. PMID: 19643933 [DOI:10.1099/jmm.0.011684-0]
23. Argent RH, Burette A, Miendje Deyi VY, Atherton JC. The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis. 2007; 45(9):1204-6. PMID: 17918084 [DOI:10.1086/522177]
24. Talebi Bezmin Abadi A. Therapy of Helicobacter pylori: present medley and future prospective. Biomed Res Int. 2014; 2014:124607. PMID: 24800203
25. Moura SB, Costa RF, Anacleto C, Rocha GA, Rocha AM, Queiroz DM. Single nucleotide polymorphisms of Helicobacter pylori dupA that lead to premature stop codons. Helicobacter. 2012; 17(3):176-80. PMID: 22515354 [DOI:10.1111/j.1523-5378.2011.00933.x]
26. Abadi AT, Taghvaei T, Wolfram L, Kusters JG. Infection with Helicobacter pylori strains lacking dupA is associated with an increased risk of gastric ulcer and gastric cancer development. J Med Microbiol. 2012; 61(Pt 1):23-30. PMID: 21903829 [DOI:10.1099/jmm.0.027052-0]
27. Abadi AT, Loffeld RJ, Constancia AC, Wagenaar JA, Kusters JG. Detection of the Helicobacter pylori dupA gene is strongly affected by the PCR design. J Microbiol Methods. 2014; 106:55-6. PMID: 25128081 [DOI:10.1016/j.mimet.2014.07.027]
28. Osman HA, Hasan H, Suppian R, Hassan S, Andee DZ, Abdul Majid N, et al. Prevalence of Helicobacter pylori cagA, babA2, and dupA genotypes and correlation with clinical outcome in Malaysian patients with dyspepsia. Turk J Med Sci. 2015; 45(4):940-6. PMID: 26422871 [DOI:10.3906/sag-1409-77]
29. Hussein NR, Tuncel IE. Helicobacter pylori dupA and smoking are associated with increased levels of interleukin-8 in gastric mucosa in Iraq. Hum Pathol. 2015; 46(6):929-30. PMID: 25791584 [DOI:10.1016/j.humpath.2015.01.021]
30. Haddadi MH, Bazargani A, Khashei R, Fattahi MR, Bagheri Lankarani K, Moini M, et al. Different distribution of Helicobacter pylori EPIYA- cagA motifs and dupA genes in the upper gastrointestinal diseases and correlation with clinical outcomes in iranian patients. Gastroenterol Hepatol Bed Bench. 2015; 8(Suppl 1):S37-46. PMID: 26171136
31. Parzecka M, Szaflarska-Poplawska A, Gasiorowska J, Gorzkiewicz M, Grzybowski T. [The prevalence of dupA (duodenal ulcer-promoting gene) of Helicobacter pylori in children and adolescents--own observation]. Pol Merkur Lekarski. 2013; 34(203):277-80. PMID: 23894779
32. Imagawa S, Ito M, Yoshihara M, Eguchi H, Tanaka S, Chayama K. Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development. J Med Microbiol. 2010; 59(Pt 12):1484-9. PMID: 20829397 [DOI:10.1099/jmm.0.021816-0]
33. Hussein NR, Argent RH, Marx CK, Patel SR, Robinson K, Atherton JC. Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells. J Infect Dis. 2010; 202(2):261-9. PMID: 20533870 [DOI:10.1086/653587]
34. Hussein NR. The association of dupA and Helicobacter pylori-related gastroduodenal diseases. Eur J Clin Microbiol Infect Dis. 2010; 29(7):817-21. PMID: 20419465 [DOI:10.1007/s10096-010-0933-z]
35. Souod N, Sarshar M, Dabiri H, Momtaz H, Kargar M, Mohammadzadeh A, et al. The study of the oipA and dupA genes in Helicobacter pylori strains and their relationship with different gastroduodenal diseases. Gastroenterol Hepatol Bed Bench. 2015; 8(Suppl 1):S47-53. PMID: 26171137
36. Roesler BM, Oliveira T, Costa SCB, Zeitune JMR. Is there any relationship between Helicobacter pylori dupA gene and the development of early and advanced gastric cancer in Brazilian patients. Journal of Medical Research and Science. 2012; 2(1):15-24.
37. Hussein NR, Tunjel I, Majed HS, Yousif ST, Aswad SI, Assafi MS. Duodenal ulcer promoting gene 1 (dupA1) is associated with A2147G clarithromycin-resistance mutation but not interleukin-8 secretion from gastric mucosa in Iraqi patients. New Microbes New Infect. 2015; 6:5-10. PMID: 26042186 [DOI:10.1016/j.nmni.2015.02.005]
38. Tomb J-F, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997; 388(6642):539-47. PMID: 9252185 [DOI:10.1038/41483]
39. Alm RA, Ling L-SL, Moir DT, King BL, Brown ED, Doig PC, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999; 397(6715):176-80. PMID: 9923682 [DOI:10.1038/16495]
40. Yamaoka Y. Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis. J Med Microbiol. 2008; 57(5):545-53. PMID: 18436586 [DOI:10.1099/jmm.0.2008/000570-0]
41. Takahashi A, Shiota S, Matsunari O, Watada M, Suzuki R, Nakachi S, et al. Intact Long‐Type dupA as a Marker for Gastroduodenal Diseases in Okinawan Subpopulation, Japan. Helicobacter. 2013; 18(1):66-72. PMID: 23067336 [DOI:10.1111/j.1523-5378.2012.00994.x]