Volume 5, Issue 1 (Feb 2017)
Res Mol Med (RMM) 2017, 5(1): 6-16 |
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Karkhane M, Marzban A, Lashgarian H E, Zali M R. Genetic Variations in Host Factors and their Critical Role on HCV Medication. Res Mol Med (RMM) 2017; 5 (1) :6-16
URL: http://rmm.mazums.ac.ir/article-1-227-en.html
URL: http://rmm.mazums.ac.ir/article-1-227-en.html
1- Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran , maryam_karkhane@hotmail.com
2- Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: (5510 Views)
Although standard treatments are nearly life-saving in hepatitis C patients, all patients equalldon’t respond to such medications. To achieve an efficient therapeutic response in all patients, medications should individually alter based on genetic factor variations. Hence, having more detailed knowledge of the affective factors on the disease promotion could help us to organize an appropriate regime to treat HCV patients. In order to review recent studies on HCV-related treatments, the data was collected from the clinical and molecular studies published during the last 15 years in electronic databases such as PubMed, Google Scholar, Medline, Scopus and Web of Sciences. Thus, this literature reviews the recent clinical studies with the genetic-based aspects, especially those factors affecting the etiopathological and histological feature of hepatitis C, diagnostic genetic and viral affecting criteria as well as some effective treatment strategies.
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