دوره 4، شماره 3 - ( 4-1395 )                   جلد 4 شماره 3 صفحات 17-21 | برگشت به فهرست نسخه ها



DOI: 10.18869/acadpub.rmm.4.3.17

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Nazari M, Nasiri M, Ghaderi A. Evaluation of Long Stress-Induced Non-coding Transcripts 5 Polymorphism in Iranian Patients with Bladder Cancer. Res Mol Med (RMM). 2016; 4 (3) :17-21
URL: http://rmm.mazums.ac.ir/article-1-198-fa.html
Evaluation of Long Stress-Induced Non-coding Transcripts 5 Polymorphism in Iranian Patients with Bladder Cancer. Research in Molecular Medicine. 1395; 4 (3) :17-21

URL: http://rmm.mazums.ac.ir/article-1-198-fa.html


چکیده:   (1078 مشاهده)

Background: Bladder cancer (BC) is the most commonly diagnosed genitourinary cancer in Iran, presented in both men and women. BC is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. Long stress-induced non-coding transcript 5 (LSINCT5), a member of the long non-coding RNAs, is abundantly expressed in high proliferative cells, as well as the cells vulnerable to cellular stress in response to chemical carcinogens.

This case-control study aimed to determine any association between LSINCT5 rs2962586 polymorphism and bladder cancer.

Materials and Methods: A group of 150 patients with BC were compared with 143 subjects as a control group. Genotyping of the rs2962586 polymorphism was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR) method.

Results: Genotype and allele distribution were not significantly different between the case and control groups. Smoking was found to be the confounding risk factor for bladder cancer.

Conclusion: Considering the result of our analyses, it seems that LSINCT5 could not affect individual susceptibility to BC among Iranian patients, however, it can be considered as a disease predictor among smokers.

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نوع مطالعه: پژوهشي | موضوع مقاله: ژنتیک
دریافت: ۱۳۹۵/۳/۲۱ | پذیرش: ۱۳۹۵/۵/۲۳ | انتشار: ۱۳۹۵/۵/۲۳

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