دوره 3، شماره 4 - ( پائیز 1394 )                   جلد 3 شماره 4 صفحات 10-16 | برگشت به فهرست نسخه ها


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Khalatbary A, Mohammadnegad B, Ghaffari E, Rafiei A. Oleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons. Res Mol Med (RMM). 2015; 3 (4) :10-16
URL: http://rmm.mazums.ac.ir/article-1-150-fa.html
Oleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons. Research in Molecular Medicine. 1394; 3 (4) :10-16

URL: http://rmm.mazums.ac.ir/article-1-150-fa.html


چکیده:   (1394 مشاهده)

Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons.

Materials and Methods: Rats were randomly divided into four groups as follow: DM treated group (12.5 mg/kg single dose), OE treated group (20 mg/kg per day), DM plus OE treated group, and vehicle group. Sections of cerebellum were taken 24 hours after deltamethrin injection and studied for histopathological and immunohistochemistry assessments.

Results: Further characteristics of degeneration in Purkinje neurons were observed in DM group compared with DM plus OE group. Compared with DM group (9.56±1.69), the positive staining for Bax in Purkinje neurones decreased in DM plus OE group (2.99±0.50) but upper than OE (0.72±0.15) and vehicle (0.57±0.03) groups. Compared with DM group (0.50±0.05), the positive staining for Bcl-2 in Purkinje neurons increased in DM plus OE group (3.29±0.18) but lower than OE (4.38±0.80) and vehicle (5.87±1.93) groups.

Conclusions: Our results suggest that DM induces apoptosis in Purkinje cells which is subsided by oleuropein.

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نوع مطالعه: پژوهشي | موضوع مقاله: آناتومي
دریافت: ۱۳۹۴/۴/۷ | پذیرش: ۱۳۹۴/۸/۶ | انتشار: ۱۳۹۴/۸/۶

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