Research in Molecular Medicine

en Uric Acid-to-Albumin Ratio and Its Association with Oxidative Stress Markers in Type 2 Diabetes Mellitus with and without Diabetic Nephropathy بیوشیمی Biochemistry پژوهشي Research <div style="text-align: justify;">Background: This study evaluated the uric acid-to-albumin ratio (UAR) and its association with oxidative stress markers and clinical parameters in patients with type 2 diabetes mellitus (DM) with and without diabetic nephropathy (DN). Methods: In this comparative cross-sectional study, diabetic patients were divided into two groups: T2DM with nephropathy and T2DM without complications. Clinical, biochemical, oxidative stress, and inflammatory markers were assessed. UAR was calculated and compared between groups. Correlations between UAR and metabolic, oxidative, inflammatory, and lipid parameters were analyzed. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performance of UAR for DN. Results: Patients with DN had significantly lower serum albumin levels and higher UAR values compared with uncomplicated diabetic patients (1.15 ± 0.33 vs. 1.09 ± 0.26, p = 0.047). Serum creatinine was significantly higher, whereas HDL and LDL cholesterol levels were lower in the DN group. UAR demonstrated a significant inverse correlation with reduced glutathione (GSH) (r = −0.364, p = 0.013) and HDL cholesterol (r = −0.250, p = 0.034), as well as positive correlations with the neutrophil-to-lymphocyte ratio (NLR) (r = 0.254, p = 0.031). No significant associations were observed between UAR and total antioxidant capacity (TAC) or most lipid and glycemic parameters. ROC analysis demonstrated poor discriminatory ability of UAR for DN (AUC = 0.551, p = 0.426). Conclusion: UAR is modestly elevated in DN group and is associated with selected oxidative stress and inflammatory markers; however, its limited diagnostic performance restricts its utility as a standalone biomarker.</div> Type 2 diabetes mellitus, Diabetic nephropathy, Uric acid-to-albumin ratio (UAR), Oxidative stress, Glutathione, Neutrophil-to-lymphocyte ratio, Albuminuria, Biomarkers, Renal dysfunction. 0 0 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1355-1&slc_lang=en&sid=1 Liela Jihad Kahayit Al-shebillawy laylajihad59@gmail.com 100319475328460014016 100319475328460014016 No Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Masoumeh Rezaei Talarposhti masoumehrezaei.cmb@gmail.com 100319475328460014017 100319475328460014017 No Molecular and Cell biology Research Center,Faculty of Medicine , Mazandaran University of Medical Sciences , Sari , Iran Zahra Alikhani zahraalikhani789@gmail.com 100319475328460014018 100319475328460014018 No Department of Medical Microbiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Hossein Mokhtari mokhtarimsh@yahoo.com 100319475328460014019 100319475328460014019 No Amol faculty of paramedicine, Mazandaran university of medical sciences, Sari, Iran. Hadis Musavi msc.musavi66@gmail.com 100319475328460014020 100319475328460014020 Yes Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Abbas Khonakdar-Tarsi khonakdarab@gmail.com 100319475328460014021 100319475328460014021 No Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.